Frank W Sellke Selected Research

Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

1/2014	Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia.
12/2012	Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome.
9/2011	Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia.
9/2010	Effects of diabetes mellitus on VEGF-induced proliferation response in bone marrow derived endothelial progenitor cells.
5/2008	Hypoxia inducible factor-1 alpha, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis.
4/2008	Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction.
12/2006	High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine.
8/2005	Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia.
6/2005	Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction.
8/2004	Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor.

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Frank W Sellke Research Topics

Disease

68	Myocardial Ischemia (Ischemic Heart Diseases) 12/2022 - 02/2002
47	Ischemia 11/2022 - 07/2002
24	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 02/2003
24	Hypercholesterolemia 01/2022 - 08/2004
24	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 07/2010
15	Reperfusion Injury 01/2015 - 02/2002
11	Hemorrhage 01/2022 - 01/2007
10	Hypoxia (Hypoxemia) 11/2022 - 12/2003
10	Coronary Disease (Coronary Heart Disease) 05/2012 - 02/2003
10	Infarction (Infarctions) 10/2011 - 02/2002
9	Stroke (Strokes) 08/2021 - 12/2008
9	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 01/2006
9	Inflammation (Inflammations) 01/2020 - 01/2007
8	Fibrosis (Cirrhosis) 12/2022 - 10/2011
7	Atrial Fibrillation 08/2021 - 10/2007
7	Myocardial Infarction 01/2019 - 02/2002
6	Hypertension (High Blood Pressure) 12/2021 - 01/2003
5	Diabetes Mellitus 11/2022 - 09/2004
5	Myocardial Reperfusion Injury 01/2016 - 10/2002
5	B-Cell Lymphoma (Lymphoma, B Cell) 09/2013 - 03/2009
4	Necrosis 03/2014 - 05/2008
3	Aortic Valve Stenosis (Aortic Stenosis) 01/2021 - 08/2014
3	Obesity 11/2019 - 08/2011
3	Atherosclerosis 11/2017 - 05/2008
3	Renal Insufficiency (Renal Failure) 08/2014 - 05/2005
3	Thrombosis (Thrombus) 03/2011 - 05/2005
2	Endocarditis 02/2022 - 12/2018
2	COVID-19 09/2021 - 01/2021
2	Peripheral Vascular Diseases (Peripheral Vascular Disease) 03/2019 - 03/2010
2	Chronic Renal Insufficiency 03/2019 - 03/2010
2	Pulmonary Atelectasis 01/2019 - 05/2018
2	Hyperglycemia 11/2017 - 12/2009
2	Cardiomegaly (Heart Hypertrophy) 01/2016 - 03/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2016 - 01/2015
2	Insulin Resistance 08/2013 - 07/2010
2	Wound Infection (Wound Infections) 11/2012 - 09/2005

Drug/Important Bio-Agent (IBA)

38	ameroidIBA 01/2022 - 03/2003
27	Proteins (Proteins, Gene)FDA Link 08/2018 - 07/2002
14	ResveratrolIBA 01/2016 - 06/2009
13	CholesterolIBA 01/2022 - 04/2008
12	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2014 - 03/2003
12	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 02/2003
10	Insulin (Novolin)FDA Link 11/2017 - 09/2005
8	Arginine (L-Arginine)FDA Link 11/2021 - 04/2004
8	Atorvastatin (Lipitor)FDA Link 02/2015 - 07/2006
7	CytokinesIBA 11/2017 - 03/2004
7	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 09/2005
6	CalpainIBA 01/2022 - 08/2015
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2015 - 07/2006
6	ChloridesIBA 12/2010 - 06/2009
6	Thrombin FDA Link 09/2010 - 05/2005
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2008 - 10/2002
5	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2021 - 04/2010
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 04/2008 - 07/2002
5	Aprotinin (Trasylol)FDA Link 01/2007 - 10/2004
4	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2022 - 02/2006
4	CollagenIBA 01/2022 - 11/2014
4	Caspase 3 (Caspase-3)IBA 01/2018 - 04/2004
4	Dabigatran FDA Link 05/2017 - 08/2015
4	idarucizumabIBA 05/2017 - 08/2015
4	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2015 - 05/2008
4	Neuropeptide YIBA 10/2013 - 12/2010
4	rusalatide acetate (Chrysalin)IBA 09/2010 - 03/2009
3	Adenosine (Adenocard)FDA LinkGeneric 11/2022 - 09/2012
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 10/2006
3	Mitogen-Activated Protein KinasesIBA 12/2018 - 11/2003
3	Glycogen Synthase KinasesIBA 01/2018 - 12/2016
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2017 - 11/2010
3	AnticoagulantsIBA 05/2017 - 08/2015
3	Oxygen (Dioxygen)IBA 01/2016 - 10/2002
3	Metformin (Glucophage)FDA LinkGeneric 11/2014 - 03/2012
3	Adenosine Monophosphate (AMP)IBA 06/2014 - 07/2009
3	Poly Adenosine Diphosphate RiboseIBA 09/2013 - 02/2002
2	AntioxidantsIBA 11/2022 - 07/2013
2	CalciumIBA 11/2022 - 12/2020
2	Serotonin (5 Hydroxytryptamine)IBA 11/2019 - 01/2012
2	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 05/2005
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 12/2018 - 06/2014
2	Apoptosis Regulatory ProteinsIBA 01/2018 - 12/2009
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2018 - 10/2011
2	Pharmaceutical PreparationsIBA 08/2016 - 12/2014
2	LigandsIBA 09/2014 - 01/2014
2	Notch ReceptorsIBA 09/2014 - 01/2014
2	Phosphotransferases (Kinase)IBA 12/2012 - 01/2008

Therapy/Procedure

28	Therapeutics 12/2022 - 02/2003
17	Cardiopulmonary Bypass (Heart-Lung Bypass) 12/2021 - 08/2003
9	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2022 - 09/2004
9	Induced Heart Arrest (Cardioplegia) 06/2017 - 08/2003
4	Transcatheter Aortic Valve Replacement 01/2021 - 08/2014
4	Stents 06/2014 - 03/2011
4	Resuscitation 01/2010 - 12/2008
4	Anesthesia 01/2010 - 12/2008
4	Critical Care (Surgical Intensive Care) 01/2010 - 12/2008
3	Length of Stay 01/2019 - 01/2019
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2011 - 04/2008
2	Percutaneous Coronary Intervention 01/2022 - 05/2016
2	Chest Tubes (Chest Tube) 01/2022 - 05/2014
2	Diet Therapy (Therapy, Diet) 11/2012 - 08/2011
2	Catheters 05/2012 - 06/2006
2	Blood Transfusion (Blood Transfusions) 04/2012 - 03/2010